By Fangjun Wang
In this thesis, the writer outlines the advance of latest monolithic columns and isotope dimethyl labeling options and their purposes in high-performance proteome analyses. notwithstanding sorts of monolithic columns were commonly built for chromatography and electrophoresis separation, their software in proteomics for complicated peptide combinations separation continues to be a problem. the writer discusses the coaching of recent monolithic columns and optimization of chromatography separation strength to enhance assurance and accuracy of proteome research. additional, the writer describes a singular on-line multidimensional chromatography method mixed with automatic on-line isotope labeling, which considerably improves the throughput, sensitivity and accuracy of quantitative proteomics. as well as the advance of recent applied sciences, the writer investigates the proteome and phosphoproteome expression alterations of medical hepatocellular carcinoma tissues and the hippocampi of mice with Alzheimer’s sickness. The paintings during this thesis has resulted in numerous courses in high-profile journals within the fields of analytical chemistry and proteome research.
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