Statics

Download Assessing the Functional Structure of Molecular Transporters by Matthias J.N.Junk PDF

By Matthias J.N.Junk

In his thesis, Matthias Junk takes an leading edge method of investigate the neighborhood constitution and dynamics of organic and artificial amphiphilic macromolecules able to transporting small molecules. changing the latter with good radicals, he makes use of state of the art electron paramagnetic resonance (EPR) spectroscopy to explain the hugely appropriate delivery functionality from the perspective of the visitor molecules. Such, he demonstrates that the sensible constitution of human serum albumin in answer considerably differs from its crystal constitution – a outcome of the protein’s adaptability to host numerous endogenous compounds and drug molecules. extra, he exhibits that the thermal cave in of thermoresponsive hydrogels and dendronized polymers results in static and dynamic heterogeneities at the nanoscale. those heterogeneities undergo effects for the material’s internet hosting homes and permit unexpected complicated catalytic functionalities.

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